RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
TLR9
RNA ID
54106
RNA Type
mRNA
Alteration Pattern
dna hypomethylation
Species
homo sapiens
Detection Methods
qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
22802293
Title
Epigenetic mechanisms through which Toll-like receptor-9 drives idiopathic pulmonary fibrosis progression
Year
2012
Function
"Hypomethylated CpG DNA drives the rapid progression of fibrotic lung disease through the differentiation of pulmonary fibroblasts into myofibroblasts through a TLR9-dependent mechanism; Toll-like receptor 9 (TLR9)-dependent macroautophagy drive the loss of Argonaute (AGO)1 and AGO2, leading to aberrant micro RNA processing, thereby promoting the rapid progression of IPF."